Publications

Tiwari, P., Blank, A., Cui, C., Schoenfelt, K.Q., Zhou, G., Xu, Y., Khramstova, G., Olopade, F., Shah, A.M., Kahn, S.A., Rosner, M.R., & Becker, L. Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer. In Press, J. Exp. Med. [Pre-Print]

Goss, C.H., Kaneko, Y., Khuu, L., Anderson, G.D., Ravishankar, S., Aitken, M.L., Lechtzin, N., Zhou, G., Czyz, D.M., McLean, K., et al. (2018). Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections. Sci. Transl. Med. 10.

Singhal, H., Greene, M.E., Zarnke, A.L., Laine, M., Al Abosy, R., Chang, Y.-F., Dembo, A.G., Schoenfelt, K., Vadhi, R., Qiu, X., et al. (2018). Progesterone receptor isoforms, agonists and antagonists differentially reprogram estrogen signaling. Oncotarget 9, 4282–4300.

Thekkan, S., Jani, M.S., Cui, C., Dan, K., Zhou, G., Becker, L., and Krishnan, Y. (2018). A DNA-based fluorescent reporter maps HOCl production in the maturing phagosome. Nat. Chem. Biol. doi: 10.1038/s41589-018-0176-3.

Reardon, C.A., Lingaraju, A., Schoenfelt, K.Q., Zhou, G., Cui, C., Jacobs-El, H., Babenko, I., Hoofnagle, A., Czyz, D., Shuman, H., Vaisar, T., & Becker, L. (2018). Obesity and insulin resistance promote atherosclerosis through an IFN-regulated macrophage protein network. Cell Rep. 23, 3021-3030.

Coats, B.R., Schoenfelt2, K.Q., Barbosa-Lorenzi, V.C., Peris, E., Cui, C., Hoffman, A., Zhou, G., Fernandez, S. Zhai, L., Hall, B.A., Haka, A.S., Shah, A.M., Reardon, C.A., Brady, M.J., Rhodes, C.J., Maxfield, F.R., & Becker, L. (2017). Metabolically activated adipose tissue macrophages perform detrimental and beneficial functions during diet-induced obesity. Cell Rep. 20, 3149-3161.

Hisert, K.B., Schoenfelt, K.Q., Cooke, G., Grogan, B., Launspach, J.L., Gallagher, C.G., Donnelly, S.C., Welsh, M.J., Singh, P.K., McKone, E.F., et al. (2016). Ivacaftor-Induced Proteomic Changes Suggest Monocyte Defects May Contribute to the Pathogenesis of Cystic Fibrosis. Am. J. Respir. Cell Mol. Biol. 54, 594–597.

Frankenburger, C., Rabe, D., Bainer, R., Sankarasharma, D., Chada, K., Krausz, T., Gilad, Y., Becker, L., & Rosner M.R. (2015) Metastasis suppressors regulate the tumor microenvironment by blocking recruitment of pro-metastatic tumor-associated macrophages. Cancer Res. 75, 4063-4073.

Pamir, N., Liu, N.-C., Irwin, A., Becker, L., Peng, Y., Ronsein, G.E., Bornfeldt, K.E., Duffield, J.S., and Heinecke, J.W. (2015). Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion. J. Biol. Chem. 290, 14656–14667.

Kratz, M., Coats, B.R., Hisert, K.B., Hagman, D., Mutsov, V., Peris, E., Schoenfelt, K.E., Kuzma, J.N., Larson, I., Billing, P.S., Landerholm, R.W., Crouthamel, M., Gozal, D., Hwang, S., Singh, P., & Becker, L. (2014). Metabolic dysfunction drives a mechanistically distinct pro-inflammatory phenotype in adipose tissue macrophages. Cell Metab. 7, 614-625. [Cover story]

Almendros, I., Wang, Y., Becker, L., Lennon, F.E., Zheng, J., Coats, B.R., Schoenfelt, K.S., Carreras, A. Hakim, F., Zhang, S.X., Farré, R., and Gozal, D. (2014) Intermittent Hypoxia-induced Changes in Tumor-associated Macrophages and Tumor Malignancy in a Mouse Model of Sleep Apnea. Am. J. Respir. Crit. Care Med. 89, 593-601.

Lee, J.-T., Pamir, N., Liu, N.-C., Kirk, E.A., Averill, M.M., Becker, L., Larson, I., Hagman, D.K., Foster-Schubert, K.E., van Yserloo, B., et al. (2014). Macrophage metalloelastase (MMP12) regulates adipose tissue expansion, insulin sensitivity, and expression of inducible nitric oxide synthase. Endocrinology 155, 3409–3420.

Yurkovetskiy, L., Burrows, M., Khan, A.A., Graham, L., Volchkov, P., Becker, L., Antonopoulos, D., Umesaki, Y., & Chervonsky, A.V. (2013). Gender bias in autoimmunity is influenced by microbiota. Immunity 39, 400-412.

Becker, L. (corresponding author), Liu, N.C., Averill, M.M., Yuan, W., Pamir, N., Peng, Y. Irwin, A.D., Fu, X., Bornfeldt, K.E., & Heinecke, J.W (2012). Unique proteomic signatures distinguish macrophages and dendritic cells. PLoS ONE. 7, e33297.

Kanter, J.E., Kramer, F., Barnhart, S., Averill, M.M., Vivekanandan-Giri, A., Vickery, T., Li, L.O., Becker, L., Yuan, W., Chait, A., Braun, K.R., Potter-Perigo, S., Sanda, S., Wight, T.N., Pennathur, S., Serhan, C.N., Heinecke, J.W., Coleman, R.A. & Bornfeldt, K.E. (2012). Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis via acyl-CoA synthetase 1. Proc. Natl. Acad. Sci. 109, E715-24.

Suzuki, M., Becker, L., Pritchard, D.K., Gharib, S.A., Wijsman, E.M., Bammler, T.K., Beyer, R.P., Vaisar, T., Oram, J.F., and Heinecke, J.W. (2012). Cholesterol accumulation regulates expression of macrophage proteins implicated in proteolysis and complement activation. Arterioscler. Thromb. Vasc. Biol. 32, 2910–2918.

Becker, L., Gharib, S.A., Wijsman, E., Vaisar, T., Oram, J.F., & Heinecke, J.W. (2010). A macrophage sterol-responsive network linked to atherogenesis. Cell Metab. 11, 125-135. [Research Highlight (2010): Nature 463, 713.]

Heinecke, N.L., Pratt, B.S., Vaisar, T., & Becker, L. (2010). PepC: Proteomics software for identifying differentially expressed proteins based on spectral counting. Bioinformatics 26, 1574-1575.

Suzuki, M., Pritchard, D.K., Becker, L., Hoofnagle, A.N., Tanimura, N., Bammler, T.K., Beyer, R.P., Bumgarner, R., Vaisar, T., de Beer, M.C., et al. (2010). High-density lipoprotein suppresses the type I interferon response, a family of potent antiviral immunoregulators, in macrophages challenged with lipopolysaccharide. Circulation 122, 1919–1927.

Becker, L., Nesheim, M.E. & Koschinsky, M.L. (2006).  Catalysis of Covalent Lp(a) Assembly: Evidence for an extracellular enzyme activity that enhances disulfide bond formation. Biochemistry. 45, 9919-9928.

Becker, L., Cook, P.M., Wright, T.G. & Koschinsky, M.L. (2004).  Quantitative evaluation of the contribution of weak lysine-binding sites present within apolipoprotein(a) Kringle IV types 6-8 to Lp(a) assembly. J Biol Chem. 279: 2679-2688.

Becker, L., Webb, B.A., Chitayat, S., Nesheim, M.E. & Koschinsky, M.L. (2003). A ligand-induced conformational change in apolipoprotein(a) enhances covalent Lp(a) formation. J Biol Chem. 278: 14074-14081.

Nesheim, M., Samis, J., Walker, J., Becker, L., Brufatto, N., Fischer, T., Tejidor, L., Jones, G., Houdijk, W., Giles, A., et al. (2002). Lipoprotein-complexed C-reactive protein and the biphasic transmittance waveform in critically ill patients. Blood Rev 16 Suppl 1, S15–22.

Toh, C.H., Samis, J., Downey, C., Walker, J., Becker, L., Brufatto, N., Tejidor, L., Jones, G., Houdijk, W., Giles, A., et al. (2002). Biphasic transmittance waveform in the APTT coagulation assay is due to the formation of a Ca(++)-dependent complex of C-reactive protein with very-low-density lipoprotein and is a novel marker of impending disseminated intravascular coagulation. Blood 100, 2522–2529.

Rahman, M.N., Becker, L., Petrounevitch, V., Hill, B.C., Jia, Z., and Koschinsky, M.L. (2002). Comparative analyses of the lysine binding site properties of apolipoprotein(a) kringle IV types 7 and 10. Biochemistry 41, 1149–1155.

Becker, L., McLeod, R.S., Marcovina, S.M., Yao, Z. & Koschinsky, M.L. (2001).  Identification of a critical lysine residue in apolipoprotein B-100 that mediates noncovalent interaction with apolipoprotein(a). J Biol Chem. 276: 36155-36162.